Fosamax on trial: Is it safe for you?
The osteoporosis drug Fosamax went on trial today in New York, facing the first of 900 lawsuits that claim the medication causes the death of jawbone tissue.
The plaintiff, Shirley Boles, 71, claims that the drug’s maker, Merck, failed to warn doctors and patients that it might hamper blood flow to the jaw, ultimately leading to osteonecrosis. Merck says there is no proof that the drug causes osteonecrosis.
Fosamax (alendronate sodium), along with generic versions of the drug, remain big sellers. Fosamax has been one of the most frequently dispensed drugs in the United States in recent years.
So, is Fosamax safe for you?
Fosamax is in a category of drugs called bisphosphonates. The category also includes Actonel and Boniva. The latter drugs, which came on the market after Fosamax, have also been linked to osteonecrosis of the jaw.
According to the FDA, Fosamax can lead to severe bone, joint or muscle pain, and the agency has advised doctors to take their patients off the drug should it occur. The FDA also asked Merck to add a warning about osteonecrosis of the jaw to its labeling. Merck’s warning currently reads:
Fosamax may cause jawbone problems in some people. Jawbone problems may include infection, and delayed healing after teeth are pulled.
Osteonecrosis of the jaw is very rare, and only a small percentage of Fosamax users have been affected by the condition. Researchers say Fosamax users are more likely to develop osteonecrosis if they have cancer or have been treated with chemotherapy, radiation or steroids. Blood clotting disorders, anemia and pre-existing dental problems have also been linked to osteonecrosis of the jaw.
Talk with your doctor about Fosamax and whether the benefits outweigh the risks for you.
August 12th, 2009 at 1:11 pm
[...] the best-selling osteoporosis drug Fosamax on trial amid allegations that it causes “jaw death” in patients, you might think healthcare [...]