Is Onglyza better than Januvia for Type 2 diabetes?
Onglyza (saxagliptin), a once-daily tablet to treat Type 2 diabetes in adults, has been approved by the FDA to compete with the other DPP-4 inhibitor on the U.S. market, Januvia (sitagliptin).
So, is Onglyza or Januvia the better choice for you?
Let’s look at the two drugs along a number of criteria –
Price. Both drugs are priced at approximately $5.72 per pill for common dosages (U.S. wholesale).
Effectiveness. Both drugs improve the body’s ability to lower elevated blood sugar levels and are part of a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. This is a relatively new class of drugs that can be taken along with older diabetes drugs, such as metformin. The potential advantages for Onglyza are (1) that it’s a smaller pill than Januvia and thus easier to swallow; and (2) that it can be taken as a once-daily combo with metformin, whereas the Janumet combo is taken twice daily.
Side effects. The most common side effects of Onglyza are the headache and runny nose that are also found with Januvia; these result from the inhibition of the immune system these drugs cause.
Safety. There is some concern that Onglyza may increase the risk of “cardiovascular events” for those who already have heart problems. The FDA is requiring Onglyza’s makers to conduct testing to address this issue. General concerns have been expressed about the potential cardiovascular risks of DPP-4 inhibitors, which is one reason similar drugs by Novartis and Takeda are still not available on the U.S. market.
In general, the prescribing information on Onglyza seems to offer no advantages over Januvia. And since the drugmaker has decided to match the price of Januvia, rather than getting in a price war, there’s no financial advantage to picking one over the other, either.
Of course, most physicians like to have more than one drug choice in the same class, because individual patients respond to medications differently. So ask your doctor.
Either way, we’re sure to get saturation TV advertising on Onglyza now that it is FDA-approved. So if you love watching pharmaceutical ads, stay tuned.
Sources: PharmaGossip, Diabetes Update, Fierce Pharma
August 22nd, 2009 at 8:57 pm
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